Maybe using coil splitting to have a single coil signal, maybe rolled back volume of the humbucker, combined with eq? But you have to tweak a lot to get near quack position sound of a strat.
A Les Paul must not always played fat and some call them a tele on stereoids
Here's a segment of Beautiful Day, Elevation and I Will Follow from Dallas 2017. Edge uses the Gibson SG for all 3 songs, where typically BD and IWF get the Explorer. Who knows what the reason was for this. I can say that I notice a big difference in the sustained harmonics of IWF.